Metabolic Syndrome Hikes Parkinson’s Risk by 39%.

In 2025, X. Zhang and a team analyzed 467,200 adults aged 37–73 from the UK Biobank, tracking them for Parkinson’s disease. They defined metabolic syndrome as having at least three of: big waist (≥102 cm men, ≥88 cm women), high blood pressure, low HDL cholesterol, high triglycerides, or high blood sugar. They checked medical records for 3,222 Parkinson’s disease cases.

Having metabolic syndrome raised Parkinson’s disease risk by 39%, with risk climbing 14% per extra metabolic syndrome trait. Those with metabolic syndrome and high genetic Parkinson’s disease risk faced a 158% higher chance. This shows metabolic syndrome, common in 37.97% of participants, is a changeable factor that boosts Parkinson’s disease odds, especially in genetically prone people.

Manage weight, blood pressure, and sugar early to lower Parkinson’s risk.