Artificial Sweeteners Wreak Havoc on Metabolic Health.

In 2025, Huang-Pin Chen and a team from National Cheng Kung University reviewed studies on low-calorie sweeteners like aspartame, sucralose, and stevia. They examined how these affect metabolism, heart health, cancer risk, and gut bacteria, pulling data from human and animal studies on blood sugar, insulin, and microbiome changes.

Sweeteners raised concerns: sucralose increased insulin resistance by 15-20% in some trials, aspartame was linked to 10-15% higher diabetes risk, and saccharin altered gut bacteria, potentially causing glucose intolerance in humans and mice. Long-term use might also raise heart disease odds by 9-17% and affect gut health, though stevia showed less harm.

Limit low-calorie sweeteners and choose natural sweets like honey or fruit to avoid metabolic risks.

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