In 2023, Mark Hyman from the UltraWellness Center reviewed research on mitochondria, the cell powerhouses that convert food to energy. They decline with age, causing fatigue, brain fog, muscle weakness, and inflammation linked to diseases like Parkinson's, diabetes, heart disease, and cancer. Exercise triggers mitophagy, clearing damaged mitochondria, with studies showing 20-30% better mitochondrial function in active people vs. sedentary.

A 2025 analysis by Georgi Dinkov highlights that polyunsaturated fats (PUFAs), prevalent in many vegetable oils, can disrupt mitochondrial function in mammals. This disruption may impair energy production and overall cellular health.