In 2023, Mark Hyman from the UltraWellness Center reviewed research on mitochondria, the cell powerhouses that convert food to energy. They decline with age, causing fatigue, brain fog, muscle weakness, and inflammation linked to diseases like Parkinson's, diabetes, heart disease, and cancer. Exercise triggers mitophagy, clearing damaged mitochondria, with studies showing 20-30% better mitochondrial function in active people vs. sedentary.

In 2025, Yimeng Wang and team from Peking University studied 88,461 UK Biobank adults who wore wrist trackers for a week, followed for 6.8 years. They checked six sleep traits, like consistent bedtimes and steady rhythms, against 172 diseases, adjusting for age, diet, and lifestyle.